Structure of the nicotinic acetylcholine receptor channel taken from reference 3
Class notes taken by students to help study different subjects related to and involving pharmaceutical sciences
Pharmacogenetics helps in identifying parts of the population based on how they react to a particular drug. In this figure it shows that pharmacogenetics helps in segregating the population according to the rate of metobolism of a particular drug.
Pharmacogenetics Basics
Figure 1 - Reaction of carbonyl containing compound with amine yields imine and enamine
Imines and Enamines – Nitrogen Analogs of Enols and Enolates
Reaction at the less reactive 6-position of 2-methyl cyclohexanone is forced due to formation of enamine
Producing and Using Imines and Enamines
Michal Addition with a michael acceptor and a michael donor - examples of reactants
Michael Addition
Base catalyzed dehydration of aldol or ketol leading to alpha,beta-unsaturated carbonyl compound.
Aldol Condensation – Base Catalyzed
Aldol condensation - leading to aldol or ketol which can undergo dehydration to produce the alpha,beta-unsaturated aldehyde or ketone
Aldol Condensation – Acid Catalyzed
Formation of a cyclic transition state during enolate formation which controls formation of E-enol or Z-enol
Directed Aldol Synthesis: Part 1 – Formation of E-Enolate and Z-Enolate
How the E-enolate selectively produce anti-product in order to obtain directed aldol synthesis.
Directed Aldol Synthesis: Part 2 – Syn and Anti control using Zimmerman Traxler principle
Synthesis of Boron Enolates for Aldol Condensation
Boron Enolates for Aldol Synthesis and Other Reactions
The Visible Spectrum with VIBGYOR (Violet, Indigo, Blue, Green, Yellow, Orange, Red)
Introduction to the Electromagnetic Spectrum and Spectroscopy
Different transitions between the bonding and anti-bonding electronic states when light energy is absorbed in UV-Visible Spectroscopy.
Ultraviolet-Visible (UV-Vis) Spectroscopy – Principle
Ergotamine - An indole alkaloid obtained from the Ergot
Pharmacognosy of Ergot (Argot or St. Anthony’s Fire)
Indole containing vinca alkaloids - Vinblastine, vincristine and vindoline.