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Notes Archive

Primary Structure of Proteins showing Peptide Backbone

An Introduction To Protein Structure

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Medicinal Chemistry of the Peripheral Nervous System – Adrenergics and Cholinergic their Biosynthesis, Metabolism and Structure Activity Relationships

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Gene Therapy

Gene Therapy

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Multicomponent Reactions

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c-MET

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Malonic Ester Synthesis – Alkylation of Enolates

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Basic conditions force ester hydrolysis and yield carboxylates.

Acetoacetic Ester Synthesis – Alkylation of Enolates

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Using the non-selective nature of acetoacetic ester synthesis and malonic ester synthesis to produce cyclic compounds

Using the non-selective nature of acetoacetic ester synthesis and malonic ester synthesis to produce cyclic compounds

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In the presence of a base alpha-hydrogens to carbonyl functional group can be abstracted very easily to yield a carbanion

Chemistry of Enolates and Enols – Acidity of Alpha-Hydrogens

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Sulfonated Bathophenanthroline, TBTA and Amineriazole

Catalytic Azide-Alkyne Cycloaddition: Reactivity and Application

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Factor Xa Inhibitors - Rivaroxaban and Apixaban

Direct Factor Xa Inhibitors as Anticoagulants

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A plasma-level time curve showing drug absorption and elimination

Determination of Absorption Rate Constant

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The gram-molecular weight of a molecule or atom has the same number of molecules or atoms which is equal to Avagadro's Number

A Primer on Measuring Concentrations – Molarity, Moles and Other Confusing Stuff

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C-alkylation vs O-alkylation - A continuous challenge in the chemistry of enolates.

Chemistry of Enolates – C vs O Alkylation

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Figure 2 - Energy profile diagram of thermodynamic product vs kinetic product

Thermodynamic Product vs Kinetic Product – with example of enolate formation of 2-methylcyclohexanone

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Examples of drugs include paracetamol and aspirin

Basic Concepts Of Pharmacology

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A picture showing different drug formulations. Taken from the cover of reference 3.

Formulation and Routes of Administration of Drugs

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A picture of a common adverse drug reaction - the skin rash (reference 3)

Adverse Drug Reactions

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C-alkylation of phenolate

Phenolates- O-alkylation and C-alkylation

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Figure showing the interplay between absorption, distribution, metabolism and excretion (ADME). Taken from reference 3.

Pharmacokinetics Basics- Absorption, Distribution, Metabolism and Excretion

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