Topics containing organic chemistry and chemical reactions
Abstraction of alpha-proton yields a carbanion which is stabilized by enol formation through resonance on either side of malonic ester
Basic conditions force ester hydrolysis and yield carboxylates.
Using the non-selective nature of acetoacetic ester synthesis and malonic ester synthesis to produce cyclic compounds
In the presence of a base alpha-hydrogens to carbonyl functional group can be abstracted very easily to yield a carbanion
Sulfonated Bathophenanthroline, TBTA and Amineriazole
C-alkylation vs O-alkylation - A continuous challenge in the chemistry of enolates.
Figure 2 - Energy profile diagram of thermodynamic product vs kinetic product
C-alkylation of phenolate
Figure 1 - Reaction of carbonyl containing compound with amine yields imine and enamine
Reaction at the less reactive 6-position of 2-methyl cyclohexanone is forced due to formation of enamine
Michal Addition with a michael acceptor and a michael donor - examples of reactants
Base catalyzed dehydration of aldol or ketol leading to alpha,beta-unsaturated carbonyl compound.
Aldol condensation - leading to aldol or ketol which can undergo dehydration to produce the alpha,beta-unsaturated aldehyde or ketone
Formation of a cyclic transition state during enolate formation which controls formation of E-enol or Z-enol
How the E-enolate selectively produce anti-product in order to obtain directed aldol synthesis.
Synthesis of Boron Enolates for Aldol Condensation
pKa scale for acidity and basicity