
Organic Chemistry Archive


Malonic Ester Synthesis – Alkylation of Enolates

Acetoacetic Ester Synthesis – Alkylation of Enolates

Using the non-selective nature of acetoacetic ester synthesis and malonic ester synthesis to produce cyclic compounds

Chemistry of Enolates and Enols – Acidity of Alpha-Hydrogens

Catalytic Azide-Alkyne Cycloaddition: Reactivity and Application

Chemistry of Enolates – C vs O Alkylation

Thermodynamic Product vs Kinetic Product – with example of enolate formation of 2-methylcyclohexanone

Phenolates- O-alkylation and C-alkylation

Imines and Enamines – Nitrogen Analogs of Enols and Enolates

Producing and Using Imines and Enamines

Michael Addition

Aldol Condensation – Base Catalyzed

Aldol Condensation – Acid Catalyzed

Directed Aldol Synthesis: Part 1 – Formation of E-Enolate and Z-Enolate

Directed Aldol Synthesis: Part 2 – Syn and Anti control using Zimmerman Traxler principle

Boron Enolates for Aldol Synthesis and Other Reactions

Henderson–Hasselbalch Equation: Derivation of pKa and pKb

Thin Layer Chromatography (TLC): Principle (with Animation)

Principle of Reversed-Phase Chromatography HPLC/UPLC (with Animation)
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