Antibiotics Archive

Animation of Antimicrobial Resistance

Animation of Antimicrobial Resistance

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New peptidoglycan synthesis occurs at the cell division plane by way of a collection of cell division machinery known as the divisome. Bacterial enzymes called autolysins, located in the divisome, break both the glycosidic bonds at the point of growth along the existing peptidoglycan, as well as the peptide cross-bridges that link the rows of sugars together. Transglycosidase enzymes then insert and link new peptidoglycan monomers into the breaks in the peptidoglycan. Finally, transpeptidase enzymes reform the peptide cross-links between the rows and layers of peptidoglycan to make the wall strong

Animation of Synthesis of Peptidoglycan Layer

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Mechanism of Action of Penicillin- by inhibition of transpeptidase and preventing the remodeling of the peptidoglycan layer

Mechanism of Action of Penicillin

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Older animation describing the mechanism of action of vancomycin by inhibition of peptidoglycan layer biosynthesis

Mechanism of Action of Vancomycin

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Mechanism of Action of Quinolones and Fluoroquinolones by inhibition of DNA gyrase (DNA topoisomerase)

Mechanism of Action of Quinolones and Fluoroquinolones

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Competitive antagonism of tetrahydrofolate biosynthesis by sulfonamides and diaminopyridines

Mechanism of Action of Tetrahydrofolate Synthesis Inhibitors – Sulfonamides and Diaminopyrimidines

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Mechanism of Translation of mRNA by tRNA in Ribosomes

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Mechanism of Action of Aminoglycosides

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Mechanism of Action of Tetracyclines

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Mechanism of Action of Macrolides

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Mechanism of Action of Oxazolidinones

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