Primary Structure of Proteins showing Peptide Backbone
Class notes taken by students to help study different subjects related to and involving pharmaceutical sciences
Abstraction of alpha-proton yields a carbanion which is stabilized by enol formation through resonance on either side of malonic ester
Malonic Ester Synthesis – Alkylation of Enolates
Basic conditions force ester hydrolysis and yield carboxylates.
Acetoacetic Ester Synthesis – Alkylation of Enolates
Using the non-selective nature of acetoacetic ester synthesis and malonic ester synthesis to produce cyclic compounds
Using the non-selective nature of acetoacetic ester synthesis and malonic ester synthesis to produce cyclic compounds
In the presence of a base alpha-hydrogens to carbonyl functional group can be abstracted very easily to yield a carbanion
Chemistry of Enolates and Enols – Acidity of Alpha-Hydrogens
Sulfonated Bathophenanthroline, TBTA and Amineriazole
Catalytic Azide-Alkyne Cycloaddition: Reactivity and Application
Factor Xa Inhibitors - Rivaroxaban and Apixaban
Direct Factor Xa Inhibitors as Anticoagulants
A plasma-level time curve showing drug absorption and elimination
Determination of Absorption Rate Constant
The gram-molecular weight of a molecule or atom has the same number of molecules or atoms which is equal to Avagadro's Number
A Primer on Measuring Concentrations – Molarity, Moles and Other Confusing Stuff
C-alkylation vs O-alkylation - A continuous challenge in the chemistry of enolates.
Chemistry of Enolates – C vs O Alkylation
Figure 2 - Energy profile diagram of thermodynamic product vs kinetic product
Thermodynamic Product vs Kinetic Product – with example of enolate formation of 2-methylcyclohexanone
Examples of drugs include paracetamol and aspirin
Basic Concepts Of Pharmacology
A picture showing different drug formulations. Taken from the cover of reference 3.
Formulation and Routes of Administration of Drugs
A picture of a common adverse drug reaction - the skin rash (reference 3)
Adverse Drug Reactions
C-alkylation of phenolate
Phenolates- O-alkylation and C-alkylation
Figure showing the interplay between absorption, distribution, metabolism and excretion (ADME). Taken from reference 3.
Pharmacokinetics Basics- Absorption, Distribution, Metabolism and Excretion
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