C-alkylation vs O-alkylation - A continuous challenge in the chemistry of enolates.
Using the non-selective nature of acetoacetic ester synthesis and malonic ester synthesis to produce cyclic compounds
Using the non-selective nature of acetoacetic ester synthesis and malonic ester synthesis to produce cyclic compounds
Basic conditions force ester hydrolysis and yield carboxylates.
Acetoacetic Ester Synthesis – Alkylation of Enolates
Abstraction of alpha-proton yields a carbanion which is stabilized by enol formation through resonance on either side of malonic ester