Presentations Archive
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Direct Renin Inhibitors as Antihypertensive Drugs
Posted on January 1, 2011 | 3 CommentsDirect renin inhibition offers another weapon in the arsenal against hypertension. -
Cryoelectron Microscopy
Posted on January 27, 2011 | No CommentsElectron microscopy, may offer a solution towards analyzing large macromolecular assemblies in their physiological state at subatomic resolutions. -
Alzheimer’s Disease and Nanotechnology
Posted on January 28, 2011 | No CommentsAlzheimer's Disease or simply Alzheimer's, is the most common form of dementia. -
Carbon Nano Tube- Synthesis
Posted on January 28, 2011 | No CommentsCarbon Nanotubes (CNTs), mostly confused with carbon fibre, are allotropes of carbon with cylindrical nanostructure . CNTs have novel properties making them useful in nanotechnology, electronics and optics. -
Multicomponent Reactions
Posted on January 28, 2011 | 1 CommentMulticomponent reactions (MCRs) are highly convergent reactions, with high atom efficiency, good bond forming capabilities and higher yields in comparison to a similar multistep reaction. -
Fluorescent labeling of biomolecules with organic probes
Posted on January 29, 2011 | No CommentsBiomolecules are mediators of various physiological processes as well as an important class of therapeutic agents and thus need to be detected and analyzed. Fluorescent labeling is an efficient method that can be used for bioanalytical purposes. These organic fluorophores have been widely used for labeling and subsequent detection of biomolecules. -
c-MET
Posted on February 4, 2011 | No CommentsMET (mesenchymal-epithelial transition factor) is a proto-oncogene that encodes a protein MET, also known asc-Met or hepatocyte growth factor receptor (HGFR). MET is a membrane receptor that is essential for embryonic development and wound healing. Hepatocyte growth factor (HGF) is the only known ligand of the MET receptor. MET is normally expressed by cells of epithelial origin, while expression of HGF is restricted to cells of mesenchymal origin. Upon HGF stimulation, MET induces several biological responses that collectively give rise to a program known as invasive growth. Abnormal MET activation in cancer correlates with poor prognosis, where aberrantly active MET triggers tumor growth, formation of new blood vessels (angiogenesis) that supply the tumor with nutrients, and cancer spread to other organs (metastasis). MET is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells andprogenitor cells express MET, which allows these cells to grow invasively in order to generate new tissues in an embryo or regenerate damaged tissues in an adult. However, cancer stem cells are thought to hijack the ability of normal stem cells to express MET, and thus become the cause of cancer persistence and spread to other sites in the body. -
Catalytic Azide-Alkyne Cycloaddition: Reactivity and Application
Posted on February 15, 2011 | No CommentsCopper catalyzed alkyne-azide cycloaddition (CuAAC) is one of the most reliable click reaction that has enabled the practical and efficient preparation of 1,4-disubstituted 1,2,3 triazoles from a wide range of substituted alkynes and azides which cannot be typically attained by the traditional Huisgen thermal cycloaddition reaction -
Direct Factor Xa Inhibitors as Anticoagulants
Posted on February 15, 2011 | No Commentsactor Xa is a zymogen of factor Xa, a serine protease, which occupies a pivotal position in the coagulation cascade. Factor Xa is found at the convergent point of extrinsic and intrinsic pathway leading to coagulation. -
Determination of Absorption Rate Constant
Posted on February 19, 2011 | 1 CommentAbsorption is characterized by evaluating the absorption rate constant ka from plasma concentration versus time data graphs. Most pharmacokinetic models assume first order kinetics for the oral absorption of the drug; however zero-order assumption can also occur -
Multiple Personality Disorder
Posted on February 25, 2011 | 1 CommentMultiple personality disorder, or MPD, is a mental disturbance classified as one of the dissociative disorders in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). It has been renamed dissociative identity disorder (DID). MPD or DID is defined as a condition in which “two or more distinct identities or personality states” exist. -
Presentation on Liposuction
Posted on March 12, 2011 | No CommentsWhile exercise and dieting may be useful for losing unwanted weight and fat, some fat deposits may not respond to efforts at weight loss. Applying liposuction techniques may be an option in these situations. -
Presentation on – CDC25 Phosphatases: A Potential Target for Novel Anticancer Agents
Posted on April 13, 2011 | No CommentsCdc25 phosphatases represent a good target for development of novel antitumor drugs. Crystal structures of Cdc25A and Cdc25B provide a rational basis for the design of potent and selective inhibitors. Further improvement of these inhibitory compounds is likely to lead to their introduction in human clinical trials. -
Applications of LC-MS (Liquid Chromatography – Mass Spectromery) in Chemical and Biochemical Sciences
Posted on July 4, 2011 | No CommentsLiquid Chromatography-Mass Spectrometry (LC-MS) is a powerful analytical tool that exploits the high resolving capabilities of LC and excellent and reliable identification of molecules by MS. -
Matrix Metalloproteinases: Its Implications in Cardiovascular Disorders
Posted on November 28, 2011 | No CommentsMatrix metalloproteinases (MMP), which are an integral part of the extracellular matrix’s enzymatic arsenal, play a major role in most of these diseases. Imbalance in the levels of MMP and TIMP plays a major role in the development of pathological conditions.