Medicinal Chemistry Archive
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Medicinal Chemistry of the Peripheral Nervous System – Adrenergics and Cholinergic their Biosynthesis, Metabolism and Structure Activity Relationships
Posted on January 27, 2011 | No CommentsA summary of the medicinal chemistry of adrenergics and cholinergic drugs including biosynthesis of norepinephrine and biosynthesis of acetylcholine, metabolism of norepinephrine and metabolism of acetylcholine and the structure activity relationship of the adrenergic and cholinergic agents. -
Catalytic Azide-Alkyne Cycloaddition: Reactivity and Application
Posted on February 15, 2011 | No CommentsCopper catalyzed alkyne-azide cycloaddition (CuAAC) is one of the most reliable click reaction that has enabled the practical and efficient preparation of 1,4-disubstituted 1,2,3 triazoles from a wide range of substituted alkynes and azides which cannot be typically attained by the traditional Huisgen thermal cycloaddition reaction -
Direct Factor Xa Inhibitors as Anticoagulants
Posted on February 15, 2011 | No Commentsactor Xa is a zymogen of factor Xa, a serine protease, which occupies a pivotal position in the coagulation cascade. Factor Xa is found at the convergent point of extrinsic and intrinsic pathway leading to coagulation.